Sex dependence of airflow limitation and air trapping in children with severe asthma
نویسندگان
چکیده
منابع مشابه
Factors associated with persistent airflow limitation in severe asthma.
Persistent airflow limitation can develop in nonsmoking patients with asthma. However, the prevalence and risk factors for airways obstruction with incomplete reversibility in asthma are unknown. We assessed the prevalence of persistent airflow limitation (defined as postbronchodilator FEV(1) or FEV(1)/VC < 75% predicted) in 132 nonsmoking outpatients with severe asthma visiting chest physician...
متن کاملRisk factors associated with irreversible airflow limitation in asthma.
PURPOSE OF REVIEW Irreversible airflow limitation develops in some patients with asthma and is related to poorer prognosis. This paper reviews recent literature on natural course, risk factors, and potential mechanisms of persistent airflow limitation in asthma. RECENT FINDINGS The natural course of persistent airflow limitation in asthma is poorly known, but reduced lung function at disease ...
متن کاملAsthma, airflow limitation and mortality risk in the general population.
Asthma and chronic obstructive pulmonary disease co-exist in a significant proportion of patients. Whether asthma increases mortality risk among subjects with airflow limitation remains controversial. We used data from 2121 adult participants in the population-based Tucson Epidemiological Study of Airway Obstructive Disease cohort. At enrolment (1972-1973), participants completed questionnaires...
متن کاملAlternative functional criteria to assess airflow-limitation reversibility in asthma.
INTRODUCTION International guidelines define significant bronchodilator response as absolute and percentage change from baseline in forced expiratory volume (FEV1) in the first second and/or forced vital capacity (FVC) ≥12% and 200 mL. However, bronchodilator effects on other lung function parameters have also been correlated to some degree of reversible airflow limitation. OBJECTIVES To dete...
متن کاملInterleukin-17 Gene Expression and Serum Levels in Children with Severe Asthma
Background: IL-17 is a major cytokine player in T cell mediated leukocyte associated inflammation. IL-17 is also recognized to participate in the pathophysiology of asthma. Objective: To determine the role of IL-17 in predicting severe asthma. Methods: We obtained serum samples from asthmatic children under the age of 5-year in three different groups of mild (n=33), moderate (n=28) and severe (...
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ژورنال
عنوان ژورنال: Journal of Allergy and Clinical Immunology
سال: 2011
ISSN: 0091-6749
DOI: 10.1016/j.jaci.2010.12.1079